Respiratory rhythms sustain biological life, governing the homeostatic exchange of oxygen and carbon dioxide. Until recently, however, the influence of breathing on the brain has largely been overlooked. Yet new evidence demonstrates that the act of breathing exerts a substantive, rhythmic influence on perception, emotion, and cognition, largely through the direct modulation of neural oscillations. Here, we synthesize these findings to motivate a new predictive coding model of respiratory brain coupling, in which breathing rhythmically modulates both local and global neural (...) gain, to optimize cognitive and affective processing. Our model further explains how respiratory rhythms interact with the topology of the functional connectome, and we highlight key implications for the computational psychiatry of disordered respiratory and interoceptive inference. (shrink)

Endothelial cells line the inside of all blood vessels, forming a structurally and functionally heterogenous population of cells. Their complexity and diversity has long been recognized, yet very little is known about the molecules and regulatory mechanisms that mediate the heterogeneity of different endothelial cell populations. The constitutive organ‐ and microenvironment‐specific phenotype of endothelial cells controls internal body compartmentation, regulating the trafficking of circulating cells to distinct vascular beds. In contrast, surface molecules associated with the activated cytokine‐inducible endothelial phenotype play (...) a critical role in pathological conditions including inflammation, tumor angiogenesis, and wound healing. Differentiation of the endothelial cell phenotypes appears to follow similar mechanisms to the differentiation of hematopoietic cells, with the exception that endothelial cells maintain transdifferentiating competence. The present review offers a scheme of endothelial cell differentially expressed endothelial cell molecules as targets for directed therapeutic intervention. (shrink)

Starting from macroscopic and microscopic facts of cerebellar histology, we propose a new functional interpretation that may elucidate the role of the cerebellum in movement control. The idea is that the cerebellum is a large collection of individual lines (Eccles's : Eccles et al. 1967a) that respond specifically to certain sequences of events in the input and in turn produce sequences of signals in the output. We believe that the sequence-in/sequence-out mode of operation is as typical for the cerebellar cortex (...) as the transformation of sets into sets of active neurons is typical for the cerebral cortex, and that both the histological differences between the two and their reciprocal functional interactions become understandable in the light of this dichotomy. The response of Purkinje cells to sequences of stimuli in the mossy fiber system was shown experimentally by Heck on surviving slices of rat and guinea pig cerebellum. Sequential activation of a row of eleven stimulating electrodes in the granular layer, imitating a of the stimuli along the folium, produces a powerful volley in the parallel fibers that strongly excites Purkinje cells, as evidenced by intracellular recording. The volley, or has maximal amplitude when the stimulus moves toward the recording site at the speed of conduction in parallel fibers, and much smaller amplitudes for lower or higher The succession of stimuli has no effect when they in the opposite direction. Synchronous activation of the stimulus electrodes also had hardly any effect. We believe that the sequences of mossy fiber activation that normally produce this effect in the intact cerebellum are a combination of motor planning relayed to the cerebellum by the cerebral cortex, and information about ongoing movement, reaching the cerebellum from the spinal cord. The output elicited by the specific sequence to which a is tuned may well be a succession of well timed inhibitory volleys the motor sequences so as to adapt them to the complicated requirements of the physics of a multijointed system. (shrink)

It is common to distinguish between “holist” and “reductionist” views of brain function, where the former envisions the brain as functioning as an indivisible unit and the latter as a collection of distinct units that serve different functions. Opposing reductionism, a number of researchers have pointed out that cortical network architecture does not respect functional boundaries, and the neuroanatomist V. Braitenberg proposed to understand the cerebral cortex as a “great mixing machine” of neuronal activity from sensory inputs, motor commands, and (...) intrinsically generated processes. In this paper, we offer a contextualization of Braitenberg’s point, and we review evidence for the interactions of neuronal activity from multiple sensory inputs and intrinsic neuronal processes in the cerebral cortex. We focus on new insights from studies on audiovisual interactions and on the influence of respiration on brain functions, which do not seem to align well with “reductionist” views of areal functional boundaries. Instead, they indicate that functional boundaries are fuzzy and context dependent. In addition, we discuss the relevance of the influence of sensory, proprioceptive, and interoceptive signals on cortical activity for understanding brain-body interactions, highlight some of the consequences of these new insights for debates on embodied cognition, and offer some suggestions for future studies. (shrink)

The present commentary considers the question of what must be learned in different types of motor skills, thereby limiting the question of what should be adjusted in the APG model in order to explain successful learning. It is concluded that an open loop model like the APG might well be able to describe the learning pattern of motor skills in a stable, predictable environment. Recent research on saccadic plasticity, however, illustrates that motor skills performed in an unpredictable environment depend heavily (...) on sensory (mostly visual) feedback, [HOUK et al.]. (shrink)

Although our idea of sequential input being a key to cerebellar function was taken seriously by most commentators, there were also objections, based in part on experimental evidence that seems to contradict our intuitions and in part on commentators' preferences for different schemes. Several were suspicious of experiments (performed on slices of cerebellar tissue) that may have severed some of the synaptic connections, particularly the inhibitory ones. It is our feeling that a modi-fication of our theory that could satisfy most (...) critics would not have to be very radical. (shrink)

This comprehensive educational history of public schools in Hawai'i shows and analyzes how dominant cultural and educational policy have affected the education experiences of Native Hawaiians. Drawing on institutional theory as a scholarly lens, the authors focus on four historical cases representing over 150 years of contact with the West. They carefully link historical events, significant people, educational policy, and law to cultural and social consequences for Native Hawaiian children and youth. The authors argue that since the early 1800s, educational (...) policy in Hawai'i emphasizing efficiency has resulted in institutional structures that have degenerated Hawaiian culture, self-image, and sovereignty. Native Hawaiians have often been denied equal access to quality schools and resulting increased economic and social status. These policies were often overtly, or covertly, racist and reflected wider cultural views prevalent across the United States regarding the assimilation of groups into the American mainstream culture. The case of education in Hawai'i is used to initiate a broader discussion of similar historical trends in assimilating children of different backgrounds into the American system of education. The scholarly analysis presented in this book draws out historical, political, cultural, and organizational implications that can be employed to understand other Native and non-Native contexts. Given the increasing cultural diversity of the United States and the perceived failure of the American educational system in light of these changes, this book provides an exceptionally appropriate starting point to begin a discussion about past, present, and future schooling for our nation's children. Because it is written and comes from a Native perspective, the value of the "insider" view is illuminated. This underlying reminder of the Native eye is woven throughout the book in _Ha'awina No'ono'o_--the sharing of thoughts from the Native Hawaiian author. With its primary focus on the education of native groups, this book is an extraordinary and useful work for scholars, thoughtful practitioners, policymakers, and those interested in Hawai'i, Hawaiian education, and educational policy and theory. (shrink)

Marcus trouva dans le livre de Dingier, L’Effondrement de la science [Dingier 1926], des arguments importants en faveur de sa propre lut­te contre la crise scientifique et culturelle de l’époque, contre l’induction et le relativisme. Une correspondance s’engagea alors entre Dingier et Marcus. Elle fut poursuivie, après la mort de ce dernier en 1928, par son ami Friedlaender/Mynona. Marcus était conscient que Dingier refusait l’apriorisme kantien, il le voyait malgré tout comme un allié. Friedlander/Mynona critiqua sévèrement l’ambivalence de Dingier, en (...) particulier ses tendances irrationalis­tes. La constellation de ces trois auteurs a été jusqu’ici ignorée par les cher­cheurs, à l’exception de H. Lütdtke [Lüdtke 1989] qui a édité la correspondance Marcus-Dingler. Cet article, qui rassemble tous les documents connus ainsi que des inédits, permet d’exemplifier le débat intemporel entre un volontarisme empiriste et opportuniste d’une part, l’idéalisme kantien d’autre part. (shrink)

Marcus trouva dans le livre de Dingier, L’Effondrement de la science [Dingier 1926], des arguments importants en faveur de sa propre lut­te contre la crise scientifique et culturelle de l’époque, contre l’induction et le relativisme. Une correspondance s’engagea alors entre Dingier et Marcus. Elle fut poursuivie, après la mort de ce dernier en 1928, par son ami Friedlaender/Mynona. Marcus était conscient que Dingier refusait l’apriorisme kantien, il le voyait malgré tout comme un allié. Friedlander/Mynona critiqua sévèrement l’ambivalence de Dingier, en (...) particulier ses tendances irrationalis­tes. La constellation de ces trois auteurs a été jusqu’ici ignorée par les cher­cheurs, à l’exception de H. Lütdtke [Lüdtke 1989] qui a édité la correspondance Marcus-Dingler. Cet article, qui rassemble tous les documents connus ainsi que des inédits, permet d’exemplifier le débat intemporel entre un volontarisme empiriste et opportuniste d’une part, l’idéalisme kantien d’autre part. (shrink)

The case of Rees v. Darlington Memorial Hospital N.H.S. Trustarises from a lower court backlash against the a prior decision of the British House of Lords in McFarlane v. Tayside Health Board. McFarlane holding that healthy children brought about by negligence in family planning procedures are blessings, and parents should therefore be denied the costs of child maintenance. But, would the House agree with the Court of Appeal in Reesthat the factual variation in that case of a disabled parent with (...) a healthy child should form an exception? In tracing the appeal of Reesto the House of Lords, this note explores their Lordships’ refusal in principle to depart from McFarlane, as well as the invocation of an autonomy-based approach to address the harm of unsolicited parenthood. In reflecting on the extent to which the wrongful conception action can be said to reinforce the value of reproductive autonomy, this note argues, nevertheless, that Reesillustrates in another way a significant departure from McFarlane, but that this is still a turn in the wrong direction. Far from resonating with women’s diverse experiences of reproduction, the law of negligence continues to illustrate little respect for reproductive choice. Therefore, this note calls for a deeper understanding of autonomy, one that recognises and embraces the diversity of individuals’ reproductive lives. (shrink)

In this paper, I consider two curious subsystems ofFrege's Grundgesetze der Arithmetik: Richard Heck's predicative fragment H, consisting of schema V together with predicative second-order comprehension (in a language containing a syntactical abstraction operator), and a theory T in monadic second-order logic, consisting of axiom V and 1 1-comprehension (in a language containing anabstraction function). I provide a consistency proof for the latter theory, thereby refuting a version of a conjecture by Heck. It is shown that both (...) class='Hi'>Heck and T prove the existence of infinitely many non-logical objects (T deriving,moreover, the nonexistence of the value-range concept). Some implications concerning the interpretation of Frege's proof of referentiality and the possibility of classifying any of these subsystems as logicist are discussed. Finally, I explore the relation of T toCantor's theorem which is somewhat surprising. (shrink)

Although to what extent Oswald Spengler served as a forerunner or precursor of National Socialism remains controversial, scholars unanimously agree that he was a virulent antidemocratic thinker. Indeed, the mere mentioning of his name immediately conjures up among students of German political philosophy associations of intense antidemocratic sentiment. The epithet of virulent opponent of democracy is certainly well-deserved for the period in his political-philosophical development when he was famous, spanning 1919, the year the heated controversy surrounding his major work The (...) Decline of the West erupted, to his untimely death in 1936. Yet what about the little-known, but important phase in the evolution of Spengler's political thought, the years immediately before the shocking military collapse of Imperial Germany and the outbreak of socialist revolution in the fall of 1918 aroused the hostility of the entire right against Germany's first democracy? These were years when Spengler, as an unknown private scholar industriously composing his chef-d'oeuvre, was politically inactive. Was Spengler passionately anti-democratic before he became an embittered man? The following investigation of this rather obscure but important period in his thought, which draws heavily upon his private papers in the Spengler Archives, surprisingly reveals that he was not vehemently antidemocratic during this time and was, in fact, a cynical and opportunistic conservative advocate of the idea of the quasi-democratization of the Second Reich. Spengler scholars, it should be noted, including among others Anton Mirko Koktanek, Gilbert Merlio, H. Stuart Hughes, Klemens von Klemperer, Horst Moller, Walter Struve and Detlef Felken, do not argue this novel position as they are not of the opinion that any significant changes in his attitude towards democratization in Germany took place in his intellectual career. (shrink)

An English language translation accompanies the original Greek text of Aristotle's book about the nature of the state, constitutions, revolutions, democracy, and oligarchy.

Ethics in business is the most urgent problem facing America today. Now two of the best-selling authors of our time, Kenneth Blanchard and Norman Vincent Peale, join forces to meet this crisis head-on in this vitally important new book. The Power of Ethical Management proves you don't have to cheat to win. It shows today's managers how to bring integrity back to the workplace. It gives hard-hitting, practical, ethical strategies that build profits, productivity, and long-term success. From a straightforward three-step (...) Ethics Check that helps you evaluate any action or decision, to the "Five P's" of ethical behavior that will clarify your purpose and your goals, The Power of Ethical Management gives you an immensely useful set of tools. These can be put to work right away to enhance the performance of your business and to enrich the quality of your life. The Power of Ethical Management is no theoretical treatise Peale and Blanchard speak from their own enormous and unique experience, They reveal the nuts and bolts, practical strategies for ethical decisions that will show you why integrity pays. "So Vince Lombardi was wrong. Winning is not the only thing as headlines and hearings from Wall Street to Washington confirm. Now comes a better game plan from the powerful one-two punch of Ken Blanchard and Norman Vincent Peale in a quickreading new book, The Power of Ethical Management. Peale and Blanchard may be the best thing that has happened to business ethics since Mike Wallace invented 60 Minutes. -- JOHN MACK CARTIER Editor-in-Chief Good Housekeeping. (shrink)

Gottlob Frege ist der Begründer der modernen Logik und einer der Väter der analytischen Philosophie. Bertrand Russell, Rudolf Carnap und Ludwig Wittgenstein haben seine Ideen aufgegriffen und weiterentwickelt. Dieses Buch liefert eine Bestandsaufnahme zu Werk und Wirkung Freges. Gewürdigt werden seine Leistungen als Logiker, Mathematiker, Sprachphilosoph und Methodologe. Im Ausgang von historischen Untersuchungen zum ursprünglichen 'kontinentalen' Ort des Frege schen Denkens wird die internationale Rezeption und das systematische Gewicht der Philosophie Frege s entfaltet. Mit Beiträgen von: Michael Astroh, Detlef (...) Gronau, Wolfgang Kienzler, Lothar Kreiser, Volker Peckhaus, Eva Picardi, Erich H. Reck, Marco Ruffino, Christiane Schildknecht, Joachim Schulte, Rainer Stuhlmann-Laeisz, Christian Thiel, Kai F. Wehmeier. (shrink)

The impact of digital media and technology on performance arts is evident when digital visual effects (VFX) filming techniques are introduced on a film set. Digital technologies influence the film actor’s approach to be congruent to and authentic within the circumstances of the scene. Actors require an effective skillset and strategies to successfully deliver an embodied performance aligning with the various digital VFX techniques. Focusing on imagination, action and emotion that would facilitate such an embodied performance, we drew on relevant (...) neuroscientific notions such as neuron reactivation, conceptual blending, as-if body states and affordances. Additionally, we incorporated relevant embodied performance concepts from Stanislavski, Laban/Bartenieff Movement Studies, Effector Patterns including the Emotional Body Approach and Lessac Kinesensics to the development of a digital acting programme, advancing the actor’s required skills and providing on-set digital acting strategies to support congruency with digital VFX and authenticity within the diegetic reality. The efficacy of this programme was determined by assessing pre- and post-intervention recordings of both a control and an experimental group of trained actors. Reflection-on-action journals from participants supplemented the assessment. The assessments and journals indicate that the acquired skillset and on-set digital acting strategies effectively improve the actor’s performance with digital VFX filming technology. (shrink)

Within the Husserlian phenomenological philosophical tradition, description and interpretation co-exist. However, teaching the practice of phenomenological psychological research requires careful articulation of the differences between a descriptive and an interpretive relationship to what is provided by qualitative data. If as researchers we neglect the epistemological foundations of our work or avoid working through difficult methodological issues, then our work invites dismissal as inadequate science, undermining the effort to strongly establish psychology along qualitative lines. The first article in this two-part discussion (...) provides a Husserlian investigation of the meaning of ‘method’ for psychology as a human science. This investigation is undertaken in the light of some researchers’ appropriations of Gadamer’s philosophical hermeneutics in the service of non-methodical praxes. The second article will address some implications of the attempt to structure qualitative psychological research along ‘Gadamerian’ lines, taking seriously the references to Gadamer’s work made by researchers such as Van Manen and Smith. Indo-Pacific Journal of Phenomenology , Volume 11, Edition 1 May 2011, 69-85. (shrink)

Man (Islam); Islamic philosophy; Islamic ethics.

Philosophy; philosophical theology; philosophical anthropology; history.

al-majmūʻah 1. Kayfa naʻmal lil-Islām -- Muqawwimāt shakhṣīyat al-Muslim -- al-Tawāzun wa-al-iʻtidāl fī ḥayāt al-Muslim.

We investigated how color preferences vary according to season and whether those changes could be explained by the ecological valence theory. To do so, we assessed the same participants’ preferences for the same colors during fall, winter, spring, and summer in the northeastern United States, where there are large seasonal changes in environmental colors. Seasonal differences were most pronounced between fall and the other three seasons. Participants liked fall-associated dark-warm colors—for example, dark-red, dark-orange, dark-yellow, and dark-chartreuse—more during fall than other (...) seasons. The EVT could explain these changes with a modified version of Palmer and Schloss’ weighted affective valence estimate procedure that added an activation term to the WAVE equation. The results indicate that color preferences change according to season, as color-associated objects become more/less activated in the observer. These seasonal changes in color preferences could not be characterized by overall shifts in weights along cone-contrast axes. (shrink)